Soft tissue tumours of the vulva

cellular angiofibroma

aggressive angiomyxoma

angiomyofibroblastoma

Median age

48

36

42

margins

usually circumscribed, may be focally infiltrative

infiltrative

circumscribed

vessels

numeous, small to medium, hyalinised

small to medium, many with hyalinised walls

numerous capillaries

cellularity

high, spindle cells, ocassional adipocytes

low, stellate cells

spindle/plump/multinucleate, perivascualr concentration

matrix

wispy collagen, may be focally myxoid

myxoid to collagenous

oedematous to collagenous

actin

-

+2

some

desmin

-

usually negative2

+2

S-100

-

-2

- 

factor VIII RA

-2

CEA

-

cytokeratin

-

-

-2

vimentin

+

variable2

+2

CD34

variable

some2

oestrogen receptor

+

+1

+

progesterone receptor

+

+1

some2