Progesterone receptor

Specific staining occurs in the nucleus. Cytoplasmic staining should be ignored.

Immunohistochemical expression

 

 

PR

ER and PR

 
 

Breast

15/292, 27/6810

13/292

 

  Invasive
ductal

44/1193

 

  Invasive lobular

5/103

 

Ovary

11/222, 6/293, 10/2410

10/222

Endometrium

2/22

1/22

Lung

0/22, 0/353, 0/2484, 17/498, 14/649, 3/4110

0/22, 0/2484, 1/498

Oesophagus

2/22

0/22

Gallbladder

0/22

0/22

Stomach

0/22, 0/393, 0/3510

0/22

Colon

0/253

 

Pancreas

0/22, 0/263, 1/2210

0/22

Kidney

0/453, 2/2710

 

Prostate

0/22

0/22

     

Diagnostic utility

References

1McCluggage WG, Patterson A, Axwell P. Aggressive angiomyxoma of pelvic parts exhibits oestrogen and progesterone receptor positivity. J Clin Pathol 2000;53:603-605.

2Lee, B. H., J. L. Hecht, et al. (2002). "WT1, estrogen receptor, and progesterone receptor as markers for breast or ovarian primary sites in metastatic adenocarcinoma to body fluids." Am J Clin Pathol 117(5): 745-50.

3Kaufmann, O., T. Deidesheimer, et al. (1996). "Immunohistochemical differentiation of metastatic breast carcinomas from metastatic adenocarcinomas of other common primary sites." Histopathology 29(3): 233-40.

4Di Nunno, L., L. G. Larsson, et al. (2000). "Estrogen and progesterone receptors in non-small cell lung cancer in 248 consecutive patients who underwent surgical resection." Arch Pathol Lab Med 124(10): 1467-70.

5Chaudhuri PK, Thomas PA, Walker MJ, Briele HA, Das Gupta TK, Beattie CW. Steroid receptors in human lung cancer cytosols. Cancer Lett 1982;16:327–332.

6Beattie, C. W., N. W. Hansen, et al. (1985). "Steroid receptors in human lung cancer." Cancer Res 45(9): 4206-14.

7Cagle, P. T., D. R. Mody, et al. (1990). "Estrogen and progesterone receptors in bronchogenic carcinoma." Cancer Res 50(20): 6632-5.

8Su JM. Hsu HK. Chang H. Lin SL. Chang HC. Huang MS. Tseng HH. Expression of estrogen and progesterone receptors in non-small-cell lung cancer: immunohistochemical study. Anticancer Research 1996;16:3803-6.

9Canver, C. C., V. A. Memoli, et al. (1994). "Sex hormone receptors in non-small-cell lung cancer in human beings." J Thorac Cardiovasc Surg 108(1): 153-7.

10Kaufmann, O., S. Kother, et al. (1998). "Use of antibodies against estrogen and progesterone receptors to identify metastatic breast and ovarian carcinomas by conventional immunohistochemical and tyramide signal amplification methods." Mod Pathol 11(4): 357-63.

©SMUHT/PW Bishop