Placental alkaline phosphatase, PLAP

Placental alkaline phosphatase is a 70 kD membrane-bound alkaline phosphatase metalloenzyme, encoded by a gene on chromosome 2q. Its function is uncertain.

 

Immunohistochemical expression

Background staining may make interpretation difficult2.

 

Embryonal rhabdomyosarcoma

8/81

 

Alveolar rhabdomyosarcoma

10/101

Leiomyoma - uterus

10/101

Leiomyoma - soft tissue

1/11

Leiomyosarcoma - uterus

5/111

Leiomyosarcoma - soft tissue

2/41

GIST

2/151

Desmoplastic small round cell tumour

15/191

Synovial sarcoma

1/91

Wilm's tumour

1/81

Myofibroblastic tumour

2/71

Neurofibroma

0/101

Schwannoma

0/101

MPNST

0/61

Traumatic neuroma

0/91

Neuroblastoma

0/101

Olfactory neuroblastoma

0/131

Ganglioneuroblastoma

0/71

Ganglioneuroma

0/11

Fibrosarcoma

0/21

Myxofibrosarcoma

0/21

Low-grade fibromyxoid sarcoma

0/21

Benign fibrous histiocytoma

0/41

Dermatofibrosarcoma protuberans

0/111

Fibromatosis

0/101

Fibroma

0/31

Nodular fasciitis

0/41

Proliferative fasciitis

0/11

Dermal scar

0/101

Ewing's sarcoma/PNET

0/141

Liposarcoma

0/111

Glomus tumour

0/31

Haemangiopericytoma

0/21

Solitary fibrous tumour

0/21

Small cell carcinoma

0/41

Carcinoid tumour

0/61

Paraganglioma

0/31

Malignant mixed Mullerian tumour

0/11

Carcinoma

0/71

Malignant mesothelioma

0/11

   

 

Diagnostic utility

References

1 Goldsmith, J.D., Pawel, B., Goldblum, J.R., Pasha, T.L., Roberts, S., Nelson, P., Khurana, J.S., Barr, F.G. and Zhang, P.J. Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation. Am J Surg Pathol 2002;26:1627-33.

2 Sung MT, Maclennan GT, Lopez-Beltran A, et al. Primary mediastinal seminoma: a comprehensive assessment integrated with histology, immunohistochemistry, and fluorescence in situ hybridization for chromosome 12p abnormalities in 23 cases. Am J Surg Pathol 2008; 32:146-55

This page last revised 22.5.2008.

©SMUHT/PW Bishop