Testicular seminoma
|
Cam5.2
|
19/641
|
|
AE1/AE3
|
23/641,
0/18(AE1 and rabbit antikeratin)4,17/415, 9/216,
5/39(cocktail of AE1/AE3, CAm5.2 and MAK-6)7,
9/26(cocktail)8
|
|
|
23/641
|
|
|
0/641
|
|
CK7
|
26/641
|
|
CK20
|
0/641
|
|
EMA
|
1/641, 0/72, 0/397
|
|
PLAP
|
64/641, 6/72,
199/199(strong in 193 and weak in 6 cases)3
|
|
CEA
|
0/72
|
|
HCG
|
0/72
|
|
AFP
|
0/72
|
|
vimentin
|
0/7
|
|
CD15
|
0/72
|
|
CD30
|
4/641, 0/72
|
|
NSE
|
7/72
|
Differential diagnosis
References
1 Cheville, J. C., Rao, S., Iczkowski, K. A., Lohse, C. M., Pankratz, V. S. Cytokeratin expression in seminoma of the human testis. Am J Clin Pathol 2000; 13: 583-8.
2 Ro J et al. Nonseminomatous germ cell tumors of the testis: an immunohistochemical study of 46 cases. Lab Invest 1991;64:50A.
3 Tissue array of a historical archive: the British Testicular Tumour Panel Series. Pathological Society January 2005, abstract 58.
4 Battifora H, Sheibani K, Tubbs RR, et al. Antikeratin antibodies in tumor diagnosis. Distinction between seminoma and embryonal carcinoma. Cancer 1984; 54:843-8
5 Miettinen M, Virtanen I,Talerman A. Intermediate filament proteins in human testis and testicular germ-cell tumors. Am J Pathol 1985; 120:402-10
6 Eglen DE,Ulbright TM. The differential diagnosis of yolk sac tumor and seminoma. Usefulness of cytokeratin, alpha-fetoprotein, and alpha-1-antitrypsin immunoperoxidase reactions. Am J Clin Pathol 1987; 88:328-32
7 Niehans GA, Manivel JC, Copland GT, et al. Immunohistochemistry of germ cell and trophoblastic neoplasms. Cancer 1988; 62:1113-23
8 Fogel M, Lifschitz-Mercer B, Moll R, et al. Heterogeneity of intermediate filament expression in human testicular seminomas. Differentiation 1990; 45:242-9
This page last revised 21.5.2008.
©SMUHT/PW Bishop