It is strongly positive in basal cells of benign prostatic acini, intermediate in PIN and negative in prostatic adenocarcinoma: weak positive staining of luminal cells leads to difficulty of interpretation in lobular atrophy and may cause confusion with the rare cases of adenocarcinoma that are positive for high molecular weight cytokeratins. It is probably most helpful in the differentiation of adenocarcinoma from PIN, while CK5/6 is superior in distinguishing adenocarcinoma from lobular atrophy2.


1Chu, P. G. and L. M. Weiss (2002). "Keratin expression in human tissues and neoplasms." Histopathology 40(5): 403-39.

2Freeman, A., K. Treurnicht, et al. (2002). "A comparison of basal cell markers used in the prostate." Histopathology 40(5): 492-4.

3Pan Histopathology 2004;45:452 **********


This page last revised 10.1.2005.


©SMUHT/PW Bishop