Soft tissue angiosarcoma

Histopathology

The histological appearances are variable:

Immunohistochemistry

antigen/clone

percentage positive

Factor VIII (monoclonal)

90

Factor VIII (polyclonal)

81

CD 34

74

CD 31

33

Fli-1

20/223

Vimentin

98

Cytokeratins

35

AE1/AE3/CK1 cocktail

45

Cytokeratin 1

59/814

EMA

0

Laminin

55

 

Differential diagnosis

Management

Prognosis

The tumour is aggressive with a median survival of 11 months.

References

1 Meis-Kindblom JM, Kindblom L-G.  Angiosarcoma of soft tissue.  A study of 80 cases.  Am J Surg Pathol 1998;22:683-97.

2 Adv Anat Pathol 1998;5:327.

3 Folpe, A. L., Chand, E. M., Goldblum, J. R., Weiss, S. W. Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics. Am J Surg Pathol 2001;25:1061-1066.

4 Chu, P. G. and L. M. Weiss (2002). "Keratin expression in human tissues and neoplasms." Histopathology 40(5): 403-39. (Summary data from multiple papers)

This page last revised 22.12.2008.