Hodgkin lymphoma and its differential diagnoses

 

 

Nodular lymphcyte predominance Hodgkin lymphoma

T-cell Histiocyte Rich Large B-Cell Lymphoma

Classical Hodgkin Lymphoma

Diffuse Large B-Cell Lymphoma

Anaplastic Large Cell Lymphoma

 

 

 

 

 

 

 

 

RS
cells

 

CD2

negative

negative

negative

negative

most cases positive

CD3

negative

negative

10% of cases positive

negative

minority of cases positive

CD15

negative

negative

most cases positive

negative

rarely focally positive

CD20

almost all cases positive

almost all cases positive

40% of cases show positivity of a minority of cells

positive

negative

CD30

rare cases weakly positive

rare cases weakly positive

positive

minority of cases positive

positive

CD43

negative

negative

negative

minority of cases positive

most cases positive

CD45

positive

positive

negative

positive

most cases positive

CD79a

positive

most cases positive

rare cases positive

positive

negative

BSAP

positive

positive

90% cases positive

positive

negative

J chain

most cases positive

most cases positive

negative

minority of cases positive

negative

Ig

most cases positive

most cases positive

negative, except for absorption of Ig

minority of cases positive

negative

BOB.1

positive

positive

negative

positive

not known

Oct-2

strongly positive

strongly positive

strongly positive in <5% of cases

positive

not known

EMA

most cases positive

most cases positive

weak expression in 5% of cases

minority of cases positive

most cases positive

ALK

negative

negative

negative

negative

most cases positive

perforin / granzyme B

negative

negative

rare cases positive

negative

positive in almost all cases

CBF.78

 

 

rare cells positive in minority of cases

 

80-90% of cases positive

BHN.9

 

 

5% cases positive

 

60% cases positive

Ig gene rearrangement

+

+

positive in 2% of cases

positive

negative

MIB/Ki67 expression

high

high

high

 

 

 

 

reactive

component

EBV

negative

negative

variable

 

 

bcl6/CD57 rosettes

numerous

negative

most cases

 

negative

Amount of TIA1 positive cells

low

very high

most cases

 

minority of cases

Amount of CD20-positive small lymphocytes

high

low

 

 

 

Histiocytes

some

variable

 

 

 

FDC

positive

 

 

 

 

 

References

World Health Organization Classification of Tumours, Tumours of the haematopoietic and lymphoid tissues, IARC Press 2001.

Pileri, S. A., S. Ascani, et al. (2002). "Hodgkin's lymphoma: the pathologist's viewpoint." J Clin Pathol 55(3): 162-76.

This page last revised 3.12.2002.

©SMUHT/PW Bishop