Minor foci of hepatoid differentiation are seen in 16%-40% of ovarian yolk sac tumours, but solid yolk sac tumour with a predominant hepatoid pattern is extremely rare. Liver cells are observed to a lesser extend in other germ cell tumours, as well as in a few ovarian sex cord stromal tumours.
Immunohistochemistry
|
2/2 (AE1/AE3+CK1)1 |
|
|
0/21 |
|
|
0/21 |
|
|
0/21 |
|
|
CEA (polyclonal) |
2/2: strong canalicular pattern1 |
|
CEA (monoclonal) |
0/21 |
|
4/82 |
|
|
0/21 |
|
|
2/2: scattered cells1 |
|
|
2/21 |
|
|
2/21 |
|
|
0/21 |
|
|
2/21 |
|
|
alpha-1-antitrypsin |
2/21 |
|
albumin |
1/21 |
Prognosis
Hepatoid yolk sac tumours of the ovary are highly aggressive.
References
2Pitman M et al. Hepatocyte paraffin 1 antibody cannot distinguish primary ovarian malignancies with hepatoid differentiation from metastatic hepatocellular carcinoma. Mod Pathol 2002;15:206A.
This page last revised 24.12.2004.