Thyroid Follicular Carcinoma-like Tumor of Kidney

Definition

A very rare renal tumour morphologically mimicking follicular carcinoma of the thyroid.

Epidemiology

A case has been reported in a 32 year old woman.

Histopathology

The tumour consists of microfollicles and macrofollicles containing inspissated colloid-like material.

Immunohistochemistry

	AE1/AE3	1/1 (intense positivity)1
	CD10	1/1 (intense positivity)1
	TTF-1	0/11
	Thyroglobulin	0/11
	35bH11	1/1 (focal cytoplasmic)1
	Vimentin	1/1 (focal cytoplasmic)1
	CK7	0/11
	CK19	0/11
	CK20	0/11
	34bE12	0/11
	CEA	0/11
	EMA	0/11
	CD15	0/11

Differential diagnosis

• Metastatic thyroid follicular carcinoma: positive for thyroglobulin and TTF-1.

References

¹ Jung SJ, Chung JI, Park SH, et al. Thyroid follicular carcinoma-like tumor of kidney: a case report with morphologic, immunohistochemical, and genetic analysis. Am J Surg Pathol 2006; 30:411-5

This page last revised 17.4.2006.

©SMUHT/PW Bishop