Anaplastic carcinoma of the thyroid
(undifferentiated carcinoma)
Immunohistochemistry
|
cytokeratin |
50% |
|
EMA |
33-55% |
|
vimentin |
50-100% |
|
thyroglobulin |
almost always negative (0/42) |
|
CEA |
squamous component may be positive |
|
TTF-1 |
2/351, 1/42 |
|
CK7 |
24/351, 0/42 |
|
CK19 |
1/1,
21/37 (12 of
13 squamoid, 7 of 7 giant cell / solid epithelioid, 2 of 7 spindle cell)3,
4/44 |
|
CK20 |
0/42 |
|
Galectin-3 |
0/1,
10/105, 5/5
(but weaker than in the papillary carcinomas)6, 3/47,
5/5 (but
weaker than in the papillary or follicular carcinomas)8 |
|
factor VIII RA |
may be focally positive |
|
bcl-2 |
14% |
bcl-2
is less often positive in anaplastic carcinoma than in insular
carcinoma.
References
Diagnostic histopathology of tumors. Edited by CDM Fletcher. 2nd
edition. Churchill Livingstone. Page 996.
1Miettinen,
M. and Franssila, K.O. Variable expression of keratins and nearly
uniform lack of thyroid transcription factor 1 in thyroid anaplastic
carcinoma. Hum Pathol 2000;31:1139-45.
2Bejarano,
P.A., Nikiforov, Y.E., Swenson, E.S. and Biddinger, P.W. Thyroid
transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin
20 in thyroid neoplasms. Appl Immunohistochem Mol Morphol 2000;8:189-94.
3Miettinen,
M. and Franssila, K.O. Variable expression of keratins and nearly
uniform lack of thyroid transcription factor 1 in thyroid anaplastic
carcinoma. Hum Pathol 2000;31:1139-45.
4Lam,
K.Y., Lo, C.Y. and Liu, M.C. Primary squamous cell carcinoma of the
thyroid gland: an entity with aggressive clinical behaviour and
distinctive cytokeratin expression profiles. Histopathology 2001;39:279-86.
5Cvejic,
D., Savin, S., Paunovic, I., Tatic, S., Havelka, M. and Sinadinovic,
J. Immunohistochemical localization of galectin-3 in malignant and
benign human thyroid tissue. Anticancer Res 1998;18:2637-41.
6Fernandez,
P.L., Merino, M.J., Gomez, M., Campo, E., Medina, T., Castronovo,
V., Sanjuan, X., Cardesa, A., Liu, F.T. and Sobel, M.E. Galectin-3
and laminin expression in neoplastic and non-neoplastic thyroid
tissue. J Pathol 1997;181:80-6.
7Gasbarri,
A., Martegani, M.P., Del Prete, F., Lucante, T., Natali, P.G. and
Bartolazzi, A. Galectin-3 and CD44v6 isoforms in the preoperative
evaluation of thyroid nodules. J Clin Oncol 1999;17:3494-502.
8Inohara,
H., Honjo, Y., Yoshii, T., Akahani, S., Yoshida, J., Hattori, K.,
Okamoto, S., Sawada, T., Raz, A. and Kubo, T. Expression of
galectin-3 in fine-needle aspirates as a diagnostic marker
differentiating benign from malignant thyroid neoplasms. Cancer 1999;85:2475-84.
This page last
revised 20.3.2003.
©SMUHT/PW Bishop