c-erbB-2 in thyroid tumours
The expression of c-erbB-2 may be restricted to papillary and
medullary carcinomas, although the published data is inconsistent.
1: using polyclonal antibody, paraffin-embedded
tissue and antigen retrieval
2: using polyclonal antibody and frozen samples.
3: using monoclonal antibody, paraffin embedded tissue but
no antigen retrieval.
4: using monoclonal antibodies, paraffin-embedded tissue
and no antigen retrieval: immunoreactivity was purely cytoplasmic.
This paper reports c-erbB-2 immunoreactivity in all types of thyroid
lesions and normal parenchyma.
5: using monoclonal antibody, paraffin-embedded tissue and
no antigen retrieval.
References
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J. C., Martin-Lacave, I., San Martin, M. V., Fernandez-Santos, J.
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D. R., Akslen, L. A., Varhaug, J. E., Lillehaug, J. R. Expression of
c-erbB-2 protein in papillary thyroid carcinomas Br J Cancer 1992;65:832-837
3Lemoine,
N. R., Wyllie, F. S., Lillehaug, J. R., Staddon, S. L., Hughes, C.
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J., et al. Absence of abnormalities of the c-erbB-1 and c-erbB-2
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P., Sambade, C., Sobrinho-Simoes, M. Expression of C-erb B2 in
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M., Springall, D. R., Varndell, I. M., Gaitonde, V. V., Hamid, Q.,
Ibrahim, N. B., Grimelius, L., Wilander, E., Polak, J. M., Coggi, G.
Oncoprotein immunoreactivity in human endocrine tumours J Pathol 1991;163:117-127
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