Leiomyosarcoma show fascicles of spindle cells with eosinophilic delicately fibrillary cytoplasm, hyperchromatic blunt-ended (cigar-shaped) nuclei and paranuclear vacuoles. There may be myxoid areas or metaplastic bone formation.
Variants:
Immunohistochemistry
|
50-100% |
relatively specific |
|
|
90% |
less specific |
|
|
positive |
not specific |
|
|
38/1001 |
||
|
0/101 |
||
|
1/121 |
||
|
0/121 |
||
|
14/401 |
||
|
0/191 |
||
|
1/121 |
||
|
1/191 |
||
|
0/121 |
||
|
occasional |
||
|
occasional |
||
|
catenin B |
occasional |
|
|
occasional |
||
Further information is available on these tumours at specific sites:
Differential diagnosis: see the immunohistochemistry of the differential diagnosis of spindle cell stromal tumours.
References
1Chu, P. G. and L. M. Weiss (2002). "Keratin expression in human tissues and neoplasms." Histopathology 40(5): 403-39. (Summary data from multiple papers)
This page last revised 4.1.2004.
©SMUHT/PW Bishop