Choroid plexus tumours

Definition

Choroid plexus tumours are intraventricular papillary neoplasms of choroid plexus epithelium. They account for 0.5% of all intracranial tumours. Choroid plexus carcinomas arise mainly in children.

	CK7	CK20	GFAP	S-100	Transthyretin	BerEP4	Cam5.2	EMA	pancytokeratin
Papilloma	24/311	3/311	24/351	19/351	31/351	1/351	33/351	4/351	27/351
Atypical papilloma	4/41

Reference 2	normal choroid plexus	choroid plexus papilloma	choroid plexus carcinoma	atypical teratoma/rhabdoid tumour	other primary brain tumours and metastatic carcinoma to brain
potassium channel Kir7.1	positive	usually positive	5/5	0/6	negative
Stanniocalcin-1	positive	positive	3/5(focal)	0/6	negative
Transthyretin	positive	usually positive	2/5	0/6	usually negative
Coagulation factor V	positive	usually negative			negative
Glutathione peroxidase 3	positive	usually negative			usually negative
Pigment epithelium derived factor	positive	usually positive			variable
Serotonin receptor 5-HTR2C	positive	usually positive			usually negative
Fibulin-1	positive	usually positive			variable
Lumican	usually positive	usually negative			negative
Plastin-1	usually positive	usually positive			usually negative
Cytokeratin 18	usually positive	usually positive			usually negative

Differential

Choroid plexus carcinoma:

metastatic carcinoma
in children: atypical teratoma/rhabdoid tumour

References

1 Gyure, K. A., Morrison, A. L. Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. Mod Pathol 2000;13:638-43.

2 Hasselblatt M, Bohm C, Tatenhorst L, et al. Identification of Novel Diagnostic Markers for Choroid Plexus Tumors: A Microarray-Based Approach. Am J Surg Pathol 2006; 30:66-74