Claudin 18 and annexin 8 in pancreatic carcinoma
These two proteins may be useful in the diagnosis of pancreatic neoplasia.
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claudin 18
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Annexin 8
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Normal pancreatic ducts
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4/105(weak cytoplasmic)1
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13/110(weak cytoplasmic; in addition, other cases showed weak punctate cytoplasmic staining)1
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Pancreatic intraepithelial neoplasia
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51/521
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0/401
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Infiltrating carcinoma
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159/166(membranous, strongest in well differentiated carcinomas)1
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149/154(both nuclear and cytoplasmic)1
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References
1 Karanjawala ZE, Illei PB, Ashfaq R, et al. New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8. Am J Surg Pathol 2008; 32:188-96
This page last revised 1.3.2008
©SMUHT/PW Bishop