Clear cell carcinoma of lung and ovary

Both pulmonary and ovarian carcinomas may be dominated by a clear cell morphology. Uncommonly, lung carcinoma metastasizes to the ovary. A panel of antibodies comprising TTF-1, CEA, CA-125 and OCT-4 appears to be useful in differentiating the origin of clear cell carcinomas between lung and ovary1.

 

 

pulmonary clear cell carcinoma

ovarian clear cell carcinoma

  

TTF-1

7/141

0/141

WT1

1/141

2/141

OCT-4

0/141

4/141

ER

1/141

2/141

PR

0/141

3/141

CEA

12/141

0/141

CA-125

1/141

14/141
     

References

1 Howell NR, Zheng W, Cheng L, et al. Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis? Int J Gynecol Pathol 2007; 26:134-40

This page last revised 22.2.2009