Differential of low grade B cell lymphomas

CD5

CD10

CD11c

CD20

CD23

CD43

CD79a

chronic lymphocytic leukaemia and small cell lymphocytic lymphoma

+

-

-

+

+

+

+

lymphoplasmacytic lymphoma

-

-

-

+

-

 var

+

mantle cell lymphoma

+

negative (distinguish CD10 positive residual germinal centres)

-

+

-

+

+

>70% cyclin D1 +

follicle centre cell lymphoma

negative (distinguish CD5 positve small T cells)

60-80%

-

+

 -

-

+

commonly bcl-6 positive

marginal zone lymphoma

rare

-

+/-

+

-

20-40%

+

usually bcl-6 negative

hairy cell leukaemia

-

-

+

+

-

-

+

plasma cell myeloma

-

-

-

+

-

+

B lymphoblastic lymphoma

-

var

-

-

-

-

+

TdT positive