HMB-45 negative melanoma

These studies examined the value of other markers in HMB-45 negative melanomas, including desmoplastic melanomas, and those mimicking peripheral nerve sheath tumours.

 

S-100

MITF (C5)

MITF (D5)

MITF (C5+D5)

Melan-A

tyrosinase

MAGE-1

  

HMB-45 positive melanoma

8/81, 42/422

4/81

7/81

8/81

8/81, 42/422

8/81, 41/422

3/81, 15/422

HBM-45 negative spindle or epithelioid melanoma

14/141, 9/92

4/141

9/141

9/141

9/141, 4/92

6/141, 5/92

11/141, 5/92

HMB-45 negative desmoplastic melanoma

8/81, 4/52

0/81

0/81

0/81

0/81, 1/52

0/81, 3/52

3/81, 3/52

MPNST

15/151

0/151

0/151

0/151

0/151

0/151

0/151

neurofibroma

11/111

0/111

0/111

0/111

0/111

0/111

0/111

Schwannoma

16/161

0/161

1/161

0/161

0/161

1/161

1/161
 

 

References

1Xu, X., Chu, A. Y., Pasha, T. L., Elder, D. E., Zhang, P. J. Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45- negative melanomas. Am J Surg Pathol 2002;26:82-87.

2Gajjar, N. A., A. J. Cochran, et al. (2004). "Is MAGE-1 Expression in Metastatic Malignant Melanomas Really Helpful?" Am J Surg Pathol 28(7): 883-8.