January 2005

CK19 has been reported to correlate strongly with behavior of pancreatic endocrine tumours.
Surprisingly, small intestinal adenocarcinomas are predominantly CK7+/CK20-.
There is more information on WT-1 in female genital tract tumours, but with conflicting information as to whether it is specific for ovarian serous tumours or also stains uterine serous tumours.
CD25 is selectively positive in neoplastic mast cells.
Views as to whether I should put effort into incorporating images vary. There is an interesting web site with an atlas of breast pathology as an illustration of web based virtual microscopy¹. I have linked one of their images of a chondrolipoma as a demonstration of the possibilities. Just click on the icon of the microscope to go to their page on mesenchymal breast tumours. Click on the thumbnail of the chondrolipoma to view a virtual slide. Let me know what you think.
Anti-PHH3 looks promising as a more objective method of counting mitoses. However, criteria will need to be recalibrated for this more sensitive method.

References