Kaposi sarcoma-associated herpesvirus, KSHV

ORF73 is a gene product expressed during latent infection. vIL-6 and K8.1 are early lytic gene products. ORF59 is also a lytic antigen. Primary effusion lymphomas, including the extra-cavitary variant, show the pattern of latent infection (ORF73+ / ORF59- / vIL-6- / K8.1-).

KSHV infection is associated with Kaposi's sarcoma, plamsablastic lymphoma and germinotropic lymphoprliferative disease.

 

 

HIV

B-cell antigens

CD30

EBV

peripheral blood involvement

 

Plasmblastic lymphoma

positive

positive

weak

always negative

yes

associated with multicentric Castleman's disease

classic PEL

positive

usually negative

positive

 

 

 

extra-cavitary PEL

positive

may be positive

positive

posiitve

np

rarely associated with multicentric Castleman's disease

Polyclonal germinotropic lymphoproliferative disease

negative

CD20 negative

negative

posiitve

 

 
             

References

1Chadburn, A., E. Hyjek, et al. (2004). "KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma." Am J Surg Pathol 28(11): 1401-16.

 

This page last revised 20.12.2004.

©SMUHT/PW Bishop