Kidney-specific cadherin

Kidney-specific cadherin is a member of the cadherin superfamily. It is a calcium-dependent membrane glycoprotein.

Immunohistochemical expression

Expression by non-neoplastic tissue is largely confined to renal epithelium, particularly to distal convoluted tubule and ascending limb of the loop of Henle. Staining is typically seen on the basolateral membrane of these cells. The collecting ducts and proximal tubules show weaker staining3. Glomeruli, interstitial cells and blood vessels are negative2.


Clear cell renal cell carcinoma

6/361, 0/1022, 6/423, 10/334


Papillary renal cell carcinoma

5/171, 1/462,4/303, 0/154

Chromophobe renal cell carcinoma

23/251, 29/302, 13/133, 31/364

Renal oncocytoma

15/201, 2/312, 19/203, 31/414

Collecting duct carcinoma


Renal medullary carcinoma


Urothelial carcinoma


Mucinous tubular and spindle cell carcinoma


Xp11 translocation carcinoma



Diagnostic utility


1 Kuehn A, Paner GP, Skinnider BF, et al. Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. Am J Surg Pathol 2007; 31:1528-33

2 Mazal PR, Exner M, Haitel A, et al. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol 2005; 36:22-8

3 Shen SS, Krishna B, Chirala R, et al. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol 2005; 18:933-40 FULL TEXT

4 Adley BP, Gupta A, Lin F, et al. Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol 2006; 126:79-85


This page last revised 26.1.2008.

©SMUHT/PW Bishop