Kidney-specific cadherin
Kidney-specific cadherin is a member of the cadherin superfamily. It is a calcium-dependent membrane glycoprotein.
Immunohistochemical expression
Expression by non-neoplastic tissue is largely confined to renal epithelium, particularly to distal convoluted tubule and ascending limb of the loop of Henle. Staining is typically seen on the basolateral membrane of these cells. The collecting ducts and proximal tubules show weaker staining3. Glomeruli, interstitial cells and blood vessels are negative2.
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Clear cell renal cell carcinoma
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6/36(staining focal membranous)1,
0/102(includes 19 granular cell variants)2, 6/423, 10/334
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Papillary renal cell carcinoma
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5/17(staining was predominantly membranous; includes positivity in 3/7 of eosinophilic type)1, 1/462,4/303, 0/154
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Chromophobe renal cell carcinoma
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23/25(staining typically strong and membranous with lesser cytoplasmic staining: the cytoplasmic staining dominates in some eosinophilic variants)1,
29/30(staining is membranous)2,
13/13(staining was membranous with basolateral accentuation)3, 31/364
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Renal oncocytoma
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15/20(staining is predominantly membranous)1,
2/31(this study used tissue microarrays, which may account for the lower rate of staining in oncocytomas, where others have found the staining to be patchy. A more dilute primary antibody was used than in other studies)2, 19/203, 31/414
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Collecting duct carcinoma
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0/31,0/32
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Renal medullary carcinoma
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0/21
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Urothelial carcinoma
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0/61
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Mucinous tubular and spindle cell carcinoma
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0/231
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Xp11 translocation carcinoma
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1/4(one case showed diffuse positivity)1
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Diagnostic utility
References
1 Kuehn A, Paner GP, Skinnider BF, et al. Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. Am J Surg Pathol 2007; 31:1528-33
2 Mazal PR, Exner M, Haitel A, et al. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol 2005; 36:22-8
3 Shen SS, Krishna B, Chirala R, et al. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol 2005; 18:933-40 FULL TEXT
4 Adley BP, Gupta A, Lin F, et al. Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol 2006; 126:79-85
This page last revised 26.1.2008.
©SMUHT/PW Bishop