Collecting duct carcinoma, Bellini tumour
Definition
This tumour is currently poorly defined.
Epidemiology
These are rare tumours.
Macroscopic appearances
These tumours occur in the renal medulla.
Histopathology
The cytological appearances are high grade. There is marked desmoplasia.
Immunohistochemistry
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Pancytokeratin KL-1
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3/5(diffuse positivity of more than 80% of tumour cells; 1, heterologous positivity of less than 50% of tumour cells; 2: study by tissue microarray)2
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34bE12
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0/5(study by tissue microarray)2
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Cam5.2
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4/5(diffuse positivity of more than 80% of tumour cells; 3, strong positivity of 50-80% of tumour cells; 1: study by tissue microarray)2
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CK7
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2/5(strong positivity of 50-80% of tumour cells in 2 cases: study by tissue microarray)2
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EMA
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3/5(diffuse positivity of more than 80% of tumour cells; 2, heterologous positivity of less than 50% of tumour cells; 1: study by tissue microarray)2, 1/34
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MOC31
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1/5(diffuse positivity of more than 80% of tumour cells in one case: study by tissue microarray)2
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BerEP4
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1/5(strong positivity of 50-80% of tumour cells in one case: study by tissue microarray)2
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RCC Ma
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2/5(strong positivity of 50-80% of tumour cells; 1, heterologous positivity of less than 50% of tumour cells; 1: study by tissue microarray)2
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CD10
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2/5(diffuse positivity of more than 80% of tumour cells; 1, heterologous positivity of less than 50% of tumour cells; 1: study by tissue microarray)2
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E-cadherin
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4/5(diffuse positivity of more than 80% of tumour cells; 2, strong positivity of 50-80% of tumour cells; 1, heterologous positivity of less than 50% of tumour cells; 1: study by tissue microarray)2
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CD15
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0/5(study by tissue microarray)2
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Vimentin
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2/5(diffuse positivity of more than 80% of tumour cells; 1, strong positivity of 50-80% of tumour cells; 1: study by tissue microarray)2, 3/34
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kidney-specific cadherin
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0/33,0/34
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P504S
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0/25
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Differential diagnosis
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Renal medullary carcinoma, which is restricted to patients with sickle cell anaemia.
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Papillary renal cell carcinoma. The cytogenetic characteristics may be crucial.
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Metastasis, suggested by the cytological appearances of scant cytoplasm and hyperchromatic nuclei.
Prognosis
References
1Renshaw, A. A. (2002). "Subclassification of renal cell neoplasms: an update for the practising pathologist." Histopathology 41(4): 283-300.
2Pan, C. C., P. C. Chen, et al. (2004). "The diagnostic utility of MOC31, BerEP4, RCC marker and CD10 in the classification of renal cell carcinoma and renal oncocytoma: an immunohistochemical analysis of 328 cases." Histopathology 45(5): 452-9.
3 Kuehn A, Paner GP, Skinnider BF, et al. Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. Am J Surg Pathol 2007; 31:1528-33
4 Mazal PR, Exner M, Haitel A, et al. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol 2005; 36:22-8
5 Tretiakova MS, Sahoo S, Takahashi M, et al. Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma. Am J Surg Pathol 2004; 28:69-76
This page last revised 2.2.2008.
©SMUHT/PW Bishop