MN/CA9

MN/CA9 is a tumour-associated antigen with a carbonic anhydrase domain.

Immunohistochemical expression

Normal fetal and adult renal tissues and benign renal lesions are negative1.
Cervical dysplasia and carcinoma.

	Renal	Clear cell carcinoma	40/40, 12/12(metastatic renal cell carcinoma)1
		Papillary carcinoma	3/3(focal)1
		Collecting duct carcinoma	2/2(focal)1
		Chromophobe carcinoma	0/21
		Oncocytoma	0/21
	Non-renal tumours	Ovary	0/81
		Endometrium	0/31
		Cervix	0/11
		Breast	0/11
		Prostate	0/21
		Female urethra	0/11

Diagnostic utility

Diagnosis of primary and metastatic renal cell carcinoma.

References

1 Liao SY, Aurelio ON, Jan K, et al. Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Cancer Res 1997; 57:2827-31 FULL TEXT

This page last revised 16.6.2007.

©SMUHT/PW Bishop