Mucinous tumour of the ovary associated with mature cystic teratoma

Most ovarian mucinous tumours are thought to arise from surface epithelium. However, 2% to 11% of mature cystic teratomas include a mucinous tumorous component and 3% to 8% of ovarian mucinous tumours contain a teratoma.

A subset of these tumours show pseudomyxoma ovarii and an intestinal immunophenotype, but are thought to arise from the ovarian teratoma.

Epidemiology

This combination of tumours occurs across a wide age range of adult women.

Histopathology

The mucinous tumour can vary forma cystadenoma through a borderline tumour, a low grade adenomatous mucinous tumour as seen in pseudomyxoma peritonei to an adenocarcinoma. It may have the appearances of a goblet cell carcinoid.

The teratomatous tumour most commonly has the appearances of a dermoid cyst.

Immunohistochemistry

	CK7+/CK20-	CK7+/CK20+	CK7-/CK20+	CK7-/CK20-	CDX-2	Villin
Mucinous tumour with teratoma without pseudomyxoma ovarii	5/231	11/231	3/231	4/231	0/211	1/211
Mucinous tumour with teratoma with pseudomyxoma ovarii	1/211	2/211	18/211	0/211	11/141	8/141

Differential diagnosis

Metastatic intestinal adenocarcinoma

References

1 Vang R, Gown AM, Zhao C, et al. Ovarian mucinous tumors associated with mature cystic teratomas: morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors in the ovary. Am J Surg Pathol 2007; 31:854-69

This page last revised 4.7.2007.