Oncocytic papillary carcinoma of the thyroid with lymphoid stroma

This is an unusual partly cystic oncocytic papillary carcinoma of the thyroid bearing a resemblance to Warthin's tumour of salivary gland.

Macroscopic appearances

These tumours are unencapsulated

Histopathology

There is a papillary architecture with papillae projecting into cystic spaces. The epithelium lining the papillae is oncocytic. Nuclear features of papillary carcinoma (optically clarity, grooving and pseudoinclusions) are present. There is a heavy infiltrate of lymphocytes and plasma cells within the tumour stroma. A peritumoral lymphocytic thyroiditis is common. Psammoma bodies may be found.

Immunohistochemistry

	epithelium	stromal
AE1/3	positive
34bE12 (K903)34bE12	weak positivity
CD15	positive
thyroglobulin	positive
mitochondrial antibody (mono-MU213-UC)	positive
S-100	some weak positivity	dendritic cells positive
calcitonin	negative
latent membrane protein	negative
LCA		lymphocytes positive
CD45RO		lymphocytes positive
CD20		lymphocytes positive

Prognosis

This tumour is less aggressive than classical papillary carcinoma

References

Ludvikova, M., Ryska, A., Korabecna, M., Rydlova, M., Michal, M.. Oncocytic papillary carcinoma with lymphoid stroma (Warthin-like tumour) of the thyroid: a distinct entity with favourable prognosis. Histopathology 2001;39:17-24.

This page last revised 1.9.2001.