Differential diagnosis
Fibroepithelial polyp of the renal pelvis |
young adult with gross painless haematuria, polypoidal filling defect in renal pelvis on IVP, thick fibrous stalk covered by normal urothelium |
|||
Fibroma |
nodule < 6mm in renal pelvis, often entrapping medullary tubules |
stromal cells: cytokeratin-, muscle markers-, CD34-, HMB45-, CD117- |
||
muscle and adipose tissue components |
||||
"patternless pattern", dense collagen bands |
||||
"patternless pattern", dense collagen bands |
||||
Sarcomatoid renal cell carcinoma |
plump spindle cells |
|||
Fibrosarcoma |
rare, monomorphic with minimal pleomorphism but a high mitotic count |
|||
Leiomyoma/leiomyosarcoma |
conspicuous pink cytoplasm |
|||
rare |
||||
Embryonal sarcoma / synovial sarcoma |
multicystic, cysts lined by hobnail cells |
vimentin+, cytokeratin focal +, EMA focal +, CD99+, CD56+, neurofilament+, S100-, CD34-, SMA-, desmin- |
||
Cellular mesoblastic nephroma |
infants, densely packed spindle/round blue cells, high mitotic rate, may entrap cystic epithelium with hobnail cells |
|||
|
CD10+, ER+, PR+, desmin variable, SMA variable, HHF-35 variable, cytokeratin-, renal cell carcinoma marker- |
|||
variable collagen, lymphoplasmacytic infiltrate |
vimentin+, SMA+, HHF-35 variable, cytokeratin variable, CD68 variable |
|||
wavy fascicles, palisading, thick-walled vessels |
S100 focal + |
|||
References
This page last revised 14.5.2004.
©SMUHT/PW Bishop