c-Jun

Cellular Jun is the analog of the viral oncogene v-Jun. Jun is a basic region-leucine zipper protein, a member the family of the activator-protein-1 transcription factors. These transcription factors are involved in cell proliferation differentiation and apoptosis. Activation of c-Jun occurs by phosphorylation.

Immunohistochemical expression

Aberrant expression occurs across the range of CD30-positive lymphomas:

 

CD30-positive lymphomas

Classical Hodgkin lymphoma

41/411

  

Anaplastic large cell lymphoma, ALK-positive

20/231

Anaplastic large cell lymphoma, ALK-negative

18/261

Cutaneous anaplastic large cell lymphoma

5/91

Lymphomatoid papulosis

11/241

Diffuse large B-cell lymphoma

4/111

CD30-negative lymphomas

Lymphocyte predominance Hodgkin lymphoma

0/121

Diffuse large B-cell lymphoma

0/351

Follicular lymphoma

0/301

Mantle cell lymphoma

0/141

MALT lymphoma

0/101

Splenic marginal zone lymphoma

0/61

CLL/SLL

0/171

Burkitt lymphoma

0/191

Plasma cell myeloma

0/261

Peripheral T-cell lymphoma

2/651
     

Diagnostic utility

 

References

1 Drakos E, Leventaki V, Schlette EJ, et al. c-Jun expression and activation are restricted to CD30+ lymphoproliferative disorders. Am J Surg Pathol 2007; 31:447-53This page last revised 21.6.2007.

©SMUHT/PW Bishop