Parathyroid neoplasms
Oxyphil neoplasms contain abundant mitochondria. The identification of malignancy in parathyroid neoplasms is problematic. Mitotic count, vascular invasion, invasion of adjacent tissues and metastasis are indications of malignancy. In difficult cases, a combination of CK14, p27 and Ki67 may be helpful.
Immunohistochemistry
|
|
CK14
|
Glut-4
|
p27 labelling index +/- SEM
|
Ki67 labelling index +/- SEM
|
|
|
oxyphil adenoma
|
35/381
|
38/381
|
66.0 +/- 2.91
|
1.9 +/- 0.21
|
|
oxyphil carcinoma
|
0/61
|
2/61
|
23.3 +/- 10.41
|
4.9 +/- 1.11
|
|
chief cell adenoma
|
5/171
|
17/171
|
60+/- 6.61
|
2.7 +/- 0.41
|
|
chief cell carcinoma
|
0/121
|
7/121
|
15.3 +/- 3.51
|
9.4 +/- 2.41
|
| |
References
1Erickson, L. A., Jin, L., Papotti, M., Lloyd, R. V. Oxyphil parathyroid carcinomas: a clinicopathologic and immunohistochemical study of 10 cases. Am J Surg Pathol 2002;26:344-349.
This page last revised 2.5.2002.
©SMUHT/PW Bishop