Large B-cell lymphoma presenting in the spleen

The spleen is most commonly involved by small B-cell lymphomas:

Less commonly, it is the presenting site of large B-cell lymphoma. These can be subdivided into:

Immunohistochemistry

 

 

Group A

Group B, other than TCRBCL

Group B, TCRBCL

(immunophenotype of the large cells)

Group C

 

CD3

0/201

0/61

0/31, 0/172

0/41

CD5

0/131

0/61

0/21

0/41

CD10

7/201

0/61

0/31, 0/172

2/41

CD15

 

 

0/31, 0/172

 

CD20

20/201

6/61

3/31, 17/172

4/41

CD30

 

 

0/31, 6/162

 

CD38

5/201

1/61

1/21

1/31

CD43

5/201

1/61

0/31

0/31

CD79a

 

 

9/92

 

CD138

 

 

0/92

 

Cyclin D1

0/191

0/61

0/31

0/41

bcl-2

11/201

5/61

3/31, 11/152

2/41

bcl-6

18/181

5/51

3/31, 17/172

2/31

Oct-2

 

 

15/152

 

IgM

 

 

7/172

 

IgD

6/201

3/61

1/31, 0/172

3/41

DBA44

0/181

1/61

0/31

2/41

p16

14/161

2/31

0/11

2/21

p53

10/201

1/61

0/31

3/41

MIB1

20/201

6/61

3/31

4/41

EMA

 

 

3/31, 8/162

 

EBER

1/141

0/31

0/31, 0/82

0/31

LMP

 

 

0/122

 

t(11;14)

0/91

0/51

 

0/41

t(14;18)

0/121

1/61

 

0/41

         

 

Differential diagnosis

1Mollejo, M., P. Algara, et al. (2003). "Large B-cell lymphoma presenting in the spleen: identification of different clinicopathologic conditions." Am J Surg Pathol 27(7): 895-902.

2Dogan, A., J. S. Burke, et al. (2003). "Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis." Am J Surg Pathol 27(7): 903-11.

This page last revised 13.1.2004.

©SMUHT/PW Bishop