Definition
A mediastinal lymphoma showing morphological and/or immunohistochemical features intermediate between those of mediastinal large B-cell lymphoma and nodular sclerosing Hodgkin lymphoma.
It is currently thought that the cell of origin of the malignant cells of Hodgkin lymphoma is a B-cell. An overlap with B-cell non-Hodgkin lymphoma is therefore not surprising.
Gray zone lymphomas, like cHL-NS and MLBCL occurs in young adults, but there is no a female predominance.
Composite cases show distinct areas of MLBCL and cHL-NS, but there are transitional areas resembling gray zone lymphoma.
Even those cases that are morphologically closer to MLBCL show an immunophenotype closer to classical Hodgkin lymphoma. Most gray zone lymphomas were positive for CD20.
|
Reference 1 |
gray zone lymphomas |
composite lymphomas |
metachronous |
|||||
|
morphology |
closer to MLBCL: n=10 |
closer to cHL: n=11 |
||||||
|
1/5 |
||||||||
|
6/10 |
8/11 |
0/5 |
4/4 |
0/6 |
6/8 |
|||
|
7/10 |
11/11 |
6/6 |
1/5 |
6/6 |
1/8 |
|||
|
10/10 |
10/11 |
2/5 |
5/5 |
4/6 |
8/8 |
|||
|
2/3 |
3/6 |
4/4 |
0/3 |
5/5 |
2/6 |
|||
|
3/4 |
7/9 |
2/2 |
0/2 |
2/3 |
0/3 |
|||
|
10/10 |
5/5 |
3/3 |
4/4 |
7/7 |
5/6 |
|||
|
BOB.1 |
8/9 |
5/5 |
4/4 |
1/3 |
6/6 |
1/6 |
||
|
8/9 |
6/6 |
3/3 |
1/3 |
6/6 |
1/7 |
|||
|
3/4 |
4/5 |
4/4 |
0/4 |
3/3 |
0/2 |
|||
|
3/4 |
4/5 |
3/3 |
1/2 |
2/2 |
1/3 |
|||
|
EBV |
||||||||
Relapses at abdominal or extranodal locations are common.
0 Tumours of the Lung, Pleura, Thymus and Heart. WHO Classification of Tumours. IARC Press 2004.
This page last revised 10.1.2006.
©SMUHT/PW Bishop