Small round cell tumours

Immunohistochemistry (this table is at an early stage of construction):

 

rhabdomyosarcoma

neuroblastoma

PNET / Ewing's sarcoma

mesenchymal chondrosarcoma

polyphenotypic small round cell tumour / intra-abdominal desmoplastic small round cell tumour

 

vimentin

always positive

 

 

more often positive in ES than in PNET

 

97%

vimentin

desmin

almost always positive

negative

negative

negative

90%

desmin

muscle-specific actin

usually positive

 

negative

negative

usually negative

muscle-specific actin

Myo-D1

82%-100% of cases

may be positive

may be positive

 

 

Myo-D1

myogenin

usually positive

 

negative

 

usually negative

myogenin

myoglobin

usually positive 

 

negative

 

 

myoglobin

NSE

 

 

most cases positive

most cases

81%

NSE

CD57

 

 

most cases positive

positive

 

CD57

neurofilament

 

 

most cases positive

 

 

neurofilament

CD99

 

 

positive

most cases positive

some cases

CD99

chromogranin

 

 

negative

 

usually negative

chromogranin

synaptophysin

 

 

 

negative

 

synaptophysin

GFAP

 

 

negative

some CNS cases may be positive

 

GFAP

cytokeratin

 

 

up to 20% of cases

some CNS cases may be positive

86%

cytokeratin

EMA

 

 

 

negative

93%

EMA

Factor VIIIRA

 

 

negative

 

 

Factor VIIIRA

Factor XIIIA

 

 

 

positive

 

Factor XIIIA

S-100

 

 

 

only chondroblastic islands are positive

 

S-100

 

embryonal rhabdomyosarcoma

neuroblastoma

PNET / Ewing's sarcoma

mesenchymal chondrosarcoma

polyphenotypic small round cell tumour / intra-abdominal desmoplastic small round cell tumour

 

References

Diagnostic Immunohistochemistry edited by Professor D. J. Dabbs, pages 78-84.

Blessing K, Grant JJh, Sanders DSA et al. Small cell malignant melanoma: a variant of naevoid melanoma. Clinicopathological features and histological differential diagnosis. J Clin Pathol 2000; 53:591-5.

3Chu, P. G. and L. M. Weiss (2002). "Keratin expression in human tissues and neoplasms." Histopathology 40(5): 403-39. (Summary data from multiple papers)

 

This page last revised 4.1.2004.

©SMUHT/PW Bishop