pleomorphic adenoma

Pleomorphic adenoma of salivary gland

Similar tumours may rarely arise from skin adnexa. A very few similar tumours have been reported as occurring in bone1.

Immunohistochemistry

 

glandular cells

myoepithelial cells

AE1/AE3

24/244

 

EMA

positive

negative

CEA

positive

negative

cytokeratin

positive

positive

cytokeratin 5/6

26/282

cytokeratin 7

9/92, 24/244

cytokeratin 14

12/122

cytokeratin 19

12/122

cytokeratin 20

0/562, 0/244

vimentin

 

positive

actin

 

variable

myosin

 

variable

S-100

variable

usually positive

GFAP

 

usually positive

Calponin

 

positive

     

Cytogenetics

Common aberrations are rearrengments of 8q12 involving the transcription facotr PLAG1, and of 12q13-15 involving the non-histone chromatin-associated protein HMGA23.

References

1 Kamiymama K et al. Aggressive mixed tumour, salivary gland type of the bone. Histopathology 2003;43:408-410.

2 Chu, P. G. and L. M. Weiss (2002). "Keratin expression in human tissues and neoplasms." Histopathology 40(5): 403-39. (Summary data from multiple papers)

3 Cheuk W,Chan JK. Advances in salivary gland pathology. Histopathology 2007; 51:1-20

4 Meer S,Altini M. CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology 2007; 51:26-32

This page last revised 4.8.2007.