Pleomorphic adenoma of salivary gland

Similar tumours may rarely arise from skin adnexa. A very few similar tumours have been reported as occurring in bone¹.

Immunohistochemistry

	glandular cells	myoepithelial cells
AE1/AE3	24/24⁴
EMA	positive	negative
CEA	positive	negative
cytokeratin	positive	positive
cytokeratin 5/6	26/28²
cytokeratin 7	9/9², 24/24⁴
cytokeratin 14	12/12²
cytokeratin 19	12/12²
cytokeratin 20	0/56², 0/24⁴
vimentin		positive
actin		variable
myosin		variable
S-100	variable	usually positive
GFAP		usually positive
Calponin		positive

Cytogenetics

Common aberrations are rearrengments of 8q12 involving the transcription facotr PLAG1, and of 12q13-15 involving the non-histone chromatin-associated protein HMGA2³.

References

¹ Kamiymama K et al. Aggressive mixed tumour, salivary gland type of the bone. Histopathology 2003;43:408-410.

² Chu, P. G. and L. M. Weiss (2002). "Keratin expression in human tissues and neoplasms." Histopathology 40(5): 403-39. (Summary data from multiple papers)

³ Cheuk W,Chan JK. Advances in salivary gland pathology. Histopathology 2007; 51:1-20

⁴ Meer S,Altini M. CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology 2007; 51:26-32

This page last revised 4.8.2007.