Rhabdomyoma

The adult type has abundant eosinophilic cytoplasm. The fetal type consists of an admixture of small cells and cells resembling fetal muscle. The juvenile type is intermediate between the other two types.

Immunohistochemistry

myoglobin

positive

desmin

positive

a-smooth muscle actin

usually negative

muscle-specific actin

positive

Myo-D1

positive

myogenin

positive

vimentin

usually negative

GFAP

usually negative

Leu-7

usually negative

CD68

usually negative

cytokeratin

usually negative

EMA

usually negative

S-100

may be focally positive

CD56

reported in one case

   

Differential diagnosis

References

Diagnostic Immunohistochemistry edited by Professor D. J. Dabbs, page 75

©SMUHT/PW Bishop