Sertoli cell tumour of testis, NOS

Clinical features

Mean age of presentation is 45 years. Usually present with a mass. Gynaecomastia is rare. Almost all cases are unilateral.

Macroscopic appearances

The tumour is usually well circumscribed and pale. There may be cyst formation.

Histopathology

The typical pattern is of hollow or slid tubules within a fibrous / hyalinised stroma. Ectatic blood vessels are common. Nuclei may be grooved, as seen in granulosa cell tumours. Cytoplasm is pale, eosinophilic or vacuolated.

Variant:

Immunohistochemistry

inhibin

10/111, 6/202

AE1/3

7/111

chromogranin

9/111

synaptophysin

5/111

S-100

7/111

CD99

1/72

EMA

negative3

CEA

negative3

PLAP

negative3

 

Differential diagnosis

Prognosis

About 12% of cases are malignant. Features associated with malignancy are3:

Sclerosing Sertoli cell tumours appear to be benign.

References

1Iczkowski, K. A., Bostwick, D. G., Roche, P. C., Cheville, J. C. Inhibin A is a sensitive and specific marker for testicular sex cord- stromal tumors. Mod Pathol 1998;11:774.

2Kommoss, F., Oliva, E., Bittinger, F., Kirkpatrick, C. J., Amin, M. B., Bhan, A. K., Young, R. H., Scully, R. E. Inhibin-alpha CD99, HEA125, PLAP, and chromogranin immunoreactivity in testicular neoplasms and the androgen insensitivity syndrome. Hum Pathol 2000;31:1055-61.

3Shanks JH, Iczkowski KA. Non-germ cell tumours of the testis. Current Diagnostic Pathology 2002;8:83-93.

This page last revised 2.12.2002.

©SMUHT/PW Bishop