Myoepithelioma

Myoepithelioma of salivary gland

Immunohistochemistry

 

benign myoepithelioma

malignant myoepithelioma

pan-cytokeratin

positive, 9/9 3

9/101

Calponin

positive

10/101

S-100

positive

10/101

GFAP

positive

5/101

muscle actin

positive

7/101

cytokeratin 7

0/72, 9/93

cytokeratin 8/18

0/172

cytokeratin 14

10/101, 5/72

cytokeratin 19

9/172

Cytokeratin 20

0/93

 

EMA

often positive

10/101

CEA

rarely positive

0/101

     

Ectomesenchymal chondromyxoid tumour of the anterior tongue may be a variant of myoepithelioma and shows the same immunoreactivity.

References

Diagnostic histopathology of tumors. Edited by CDM Fletcher. 2nd edition. Churchill Livingstone. Page 249.

1 Nagao, T et al. Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. Cancer 1998;83:1292-9.

2 Chu, P. G. and L. M. Weiss (2002). "Keratin expression in human tissues and neoplasms." Histopathology 40(5): 403-39. (Summary data from multiple papers)

3 Meer S,Altini M. CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology 2007; 51:26-32

This page last revised 4.8.2007.

©SMUHT/PW Bishop