Myoepithelioma of salivary gland

Immunohistochemistry

	benign myoepithelioma	malignant myoepithelioma
pan-cytokeratin	positive, 9/9 (AE1/AE3)³	9/10¹
Calponin	positive	10/10¹
S-100	positive	10/10¹
GFAP	positive	5/10¹
muscle actin	positive	7/10¹
cytokeratin 7	0/7², 9/9³
cytokeratin 8/18	0/17²
cytokeratin 14	10/10¹, 5/7²
cytokeratin 19	9/17²
Cytokeratin 20	0/9³
EMA	often positive	10/10¹
CEA	rarely positive	0/10¹

Ectomesenchymal chondromyxoid tumour of the anterior tongue may be a variant of myoepithelioma and shows the same immunoreactivity.

References

Diagnostic histopathology of tumors. Edited by CDM Fletcher. 2nd edition. Churchill Livingstone. Page 249.

¹ Nagao, T et al. Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. Cancer 1998;83:1292-9.

² Chu, P. G. and L. M. Weiss (2002). "Keratin expression in human tissues and neoplasms." Histopathology 40(5): 403-39. (Summary data from multiple papers)

³ Meer S,Altini M. CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology 2007; 51:26-32

This page last revised 4.8.2007.

©SMUHT/PW Bishop