|
Cam5.2
|
0/1(breast)1,
0/1(pancreas)3,
0/1(base of skull, malignant)7
|
|
|
AE1/3
|
0/1(breast)1,
0/1(pancreas)3,
0/1(base of skull, malignant)7,
3/23(5-25% of cells)12
|
|
KL1
|
0/1(pancreas)3
|
|
Pancytokeratin
|
0/1(common bile duct)6,
0/1(subcutis over knee, malignant)8,
0/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components)9
|
|
CK7
|
0/1(base of skull, malignant)7
|
|
Desmin
|
0/1(breast)1,
0/1(base of skull, malignant)7,
0/1(subcutis over knee, malignant)8,
1/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components: spindle cell component weakly positive)9,
0/1(uterus)10,
8/22(>50% of cells: 3 cases, 25-50% of cells: 1 case, 5-25% of cells: 4 cases)12
|
|
Muscle-specific actin
|
0/1(breast)1,
0/1(base of skull, malignant, equivocal staining of a few cells)7,
1/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components: spindle cell component moderately positive)9
|
|
SMA
|
0/1(breast)1,
0/1(common bile duct)6,
1/1(base of skull, malignant, scattered cells positive)7,
1/1(subcutis over knee, malignant: variable, focally strong positivity)8,
1/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components: spindle cell component strongly positive)9,
0/1(uterus)10,
20/25(>50% of cells: 7 cases, 25-50% of cells: 5 cases, 5-25% of cells: 9 cases : positivity was greater in epithelioid than in spindle cells) 12
|
|
S-100
|
0/1(breast)1,
0/1(common bile duct)6,
0/1(base of skull, malignant)7,
0/1(subcutis over knee, malignant)8,
0/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components)9,
0/1(uterus)10,
8/24(>50% of cells: 2 cases, 25-50% of cells: 3 cases, 5-25% of cells: 3 cases)12
|
|
HMB45
|
1/1(breast)1,
1/1(pancreas)3,
1/1(uterus)4,
4/4(2 rectum, 1 heart, 1 perineum)5,
1/1(common bile duct)6,
1/1(base of skull, malignant, scattered cells positive)7,
1/1(subcutis over knee, malignant: strong diffuse positivity)8,
1/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components: both components positive)9,
1/1(uterus)10,
22/24(>50% of cells: 9 cases, 25-50% of cells: 5 cases, 5-25% of cells: 8 cases)12
|
|
Melan-A (MART-1)
|
1/1(breast)1,
0/1(common bile duct)6,
0/1(base of skull, malignant, equivocal staining of a few cells)7,
1/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components: both components positive)9,
13/18(>50% of cells: 1 case, 25-50% of cells: 5 cases, 5-25% of cells: 7 cases)12
|
|
Co-expression of (HBM45 or Melan-A) and SMA
|
20/2412
|
|
MiTF
|
9/18(>50% of cells: 4 cases, 25-50% of cells: 2 cases, 5-25% of cells: 3 cases)12
|
|
TFE3
|
5/17(>50% of cells: 3 cases, 25-50% of cells: 2 cases)12
|
|
NKI/C3
|
1/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components: both components positive)9
|
|
KBA.62
|
0/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components: both components negative)9
|
|
Oestrogen receptor
|
0/1(breast)1,
1/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components)9,
0/1(uterus)10
|
|
Progesterone receptor
|
1/1(breast)1,
0/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components)9,
1/1(uterus)10
|
|
EMA
|
0/1(breast)1,
0/1(common bile duct)6,
0/1(base of skull, malignant)7,
0/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components)9
|
|
Vimentin
|
0/1(breast)1,
0/1(common bile duct)6,
0/1(base of skull, malignant, equivocal staining of a few cells)7,
1/1(uterus)10,
12/14(>50% of cells: 10 cases, 25-50% of cells: 2 cases)12
|
|
NSE
|
0/1(breast)1,
0/1(pancreas)3,
1/1(common bile duct)6,
0/1(base of skull, malignant)7
|
|
Chromogranin A
|
0/1(breast)1,
0/1(pancreas)3,
0/1(common bile duct)6,
0/1(base of skull, malignant)7,
0/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components)9
|
|
Synaptophysin
|
0/1(breast)1,
0/1(common bile duct)6,
0/1(base of skull, malignant)7
|
|
Neu-N
|
0/1(base of skull, malignant)7
|
|
CEA
|
0/1(breast)1,
0/1(base of skull, malignant)7,
0/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components)9
|
|
CD10
|
1/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components: both components strongly positive)9
|
|
CD31
|
0/1(breast)1
|
|
CD34
|
0/1(breast)1,
0/1(subcutis over knee, malignant)8,
0/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components)9,
0/1(uterus)10, 0/712
|
|
CD45
|
0/1(base of skull, malignant)7,
0/1(subcutis over knee, malignant)8
|
|
|
CD99
|
1/1(base of skull, malignant)7
|
|
|
CD117
|
1/1(malignant rectovaginal tumour: biphasic tumour composed of spindle cell and epithelioid components)9,
1/1(uterus)10,
1/20( 25-50% of cells)12
|
|
|
Alpha-fetoprotein
|
0/1(base of skull, malignant)7
|
|
|
Placental alkaline phosphatase
|
0/1(base of skull, malignant)7
|
|
|
b-HCG
|
0/1(base of skull, malignant)7
|
|
|
p16
|
0/1(uterus)10
|
|
| |
|
|
Site
|
Differential
|
distinguishing features
|
|
|
General
|
clear cell carcinoma, glycogen-rich
|
cytokeratin positive, HMB-45 negative
|
|
clear cell carcinoma, lipid-rich
|
cytokeratin positive, HMB-45 negative
|
|
metastatic melanoma
|
HMB-45 positive
|
|
Abdomen
|
GIST: PEComa may be CD117+
|
|
|
Kidney
|
renal clear cell carcinoma
|
cytokeratin positive, HMB-45 negative
|
|
Breast
|
clear cell adenomyoepithelioma
|
cytokeratin, actin and S-100 positive, HMB-45 negative
|
|
Breast
|
clear cell myoepithelioma
|
cytokeratin, actin and S-100 positive, HMB-45 negative
|
|
Base of skull
|
chordoma, chondrosarcoma, meningioma, pituitary adenoma, haemangioblastoma
|
|
|
Soft tissues
|
clear cell sarcoma of soft tissue
|
S-100 positive
|
|
clear cell rhabdomyosarcoma
|
desmin, myogenin, myoD1 positive
|
|
alveolar soft part sarcoma
|
PAS positive
|
| |